Tomato Sauce Put to the Test for Prostate Cancer

What happened when cancer patients were given three quarterss of a cup of canned tomato sauce every day for three weeks?

“Occasionally…positive things happen in the field of cancer prevention discipline to popular, good-tasting foods.” Cruciferous veggies like broccoli are wonderful, but they may be “a hard-bitten menu for the public to swallow.” By contrast, who doesn’t like tomatoes?

As I’ve discussed previously, studies using high-dose adds-on of lycopene, the antioxidant red stain in tomatoes thought to be the active anti-cancer ingredient, miscarried over and over again to prevent or plow cancer. In knowledge, it may even end up promoting cancer, since lycopene may actually act as a pro-oxidant at the high levels one can get with adds-on. But, lycopene in add-on formation doesn’t appear proved effective at very low doses either. “There is a strong inverse[ protective] correlation between the intake of fruit and vegetables and the incidence of certain cancers.” However, when we supplement with simply a single compound isolated in capsule form, we may upset the healthy, natural balance of antioxidants.

It does seem to be fairly the human hubris to think we can reproduce the beneficial effects of consuming entire fruits and vegetables by leave augments of a single phytochemical, which would normally interact with thousands of other combinations in the natural matrix Mother Nature aimed. “In addition to lycopene,[ other] known carotenoids in tomatoes and tomato-based concoctions include b-carotene, g-carotene, z-carotene, phytofluene, and phytoene, all of which…have been found to accumulate in human prostate tissue.” There is still countless non-carotenoid complexes in tomatoes that may have anti-cancer activity , not to mention all of the combinations we have yet to even characterize.

It’s not about knowing the one magic bullet, though. As one study claim reads, “The anti-cancer effects of carotenoids and other phytonutrients resides in their mixed activity.” For example, as you can see at 1:52 in my video Tomato Sauce vs. Prostate Cancer, at the low concentrations of the tomato combinations phytoene, phytofluene, and lycopene that are found in most people who dine ordinary sums of tomatoes, there’s very little effect on cancer cadre swelling in vitro when employed separately. But, when they are combined together, a non-effective dose of phytoene and phytofluene plus a non-effective dose of lycopene somehow become effective, greatly checking prostate cancer cell growth. The same synergy can be seen across meat. Curcumin, the yellowish stain in turmeric and curry powder, tomato obtains, and the vitamin E is located within nuts and grains do little independently to impede pro-growth signaling of prostate cancer cells–less than 10 percent–but all three together suppress emergence signaling about 70 percent. The entire be higher than resources in the amount of its parts.

So, instead of giving cancer cases lycopene pills, what if we give them some tomato sauce? Investigates gave 32 patients with localised prostate cancer three one-fourths of a bowl of canned tomato sauce every day for three weeks before their scheduled radical prostatectomy. In their bloodstream, PSA ranks dropped by 17.5 percent. PSA, prostate-specific antigen, is a protein produced by prostate gland cadres, and heightened blood PSA positions are routinely used to monitor the success of cancer treatment. “It was surprising to find that the 3-week, tomato sauce-based dietary intervention” could lessen PSA concentrations in souls with prostate cancer. As well, free radical damage of the DNA in their white blood cells dropped by 21 percentage. Imagine how antioxidant-poor their diet must have been beforehand if less than one cup of tomato sauce a daylight could abbreviate DNA damage by more than a fifth!

What did they find in their prostates, though? Human prostate tissue is thought to be “particularly vulnerable to oxidative DNA damage by free radicals, which are thought to play a critical role in all stages of carcinogenesis, ” that is, of cancer pattern. This may be for a number of reasons, including fewer DNA repair enzymes. Well, health researchers had tissue samples taken from biopsies before the tomato sauce regimen started, as well as tissue tests from surgeries after three weeks of tomato sauce, and resected tissues from tomato sauce-supplemented cases had 28 percentage less free radical damage than expected. I testify a diagram of the DNA damage in the prostate before the tomato sauce and after time 20 days of sauce at 4:18 in my video. You can be found in the fell yourself. What’s interesting is there was no association between the level of lycopene in the prostate and the protective gists. Tomatoes contain a entire bunch of things, some of which may be even more powerful than lycopene.

Regardless, in contrast to the lycopene augments alone, the whole food intervention seemed to help. To see if lycopene comedies any character at all, one would have to test a lycopene-free tomato–in other words, a yellow-bellied tomato. So, what if you likened red tomatoes to yellow tomatoes, which have all the non-lycopene tomato compounds, to straight lycopene in a pill? Researchers fed parties red tomato adhesive, yellow tomato glue, lycopene pills, or placebo capsules, and then dripped their blood onto prostate cancer cells to increase by a petri dish. As “youre seeing” at 5:18 in my video, the pink tomato serum–the blood from those who ate red tomato paste–significantly decreased the prostate cancer cell’s expression of a growth-promoting gene announced cyclin D1, compared to those not ingesting anything. This downregulation of the gene by the red tomato intake “may contribute to lower prostate cancer jeopardy by limiting cell proliferation.” The red tomato seemed to work better than the yellowish tomato, so perhaps the lycopene helped–but not in pill constitute. This gene “was not regulated” by the lycopene pill serum, indicating that it may be something else. And, lycopene alone significantly upregulated procarcinogenic genes. “Therefore, it can be stated that tomato consumption may be preferable to unadulterated lycopene…”

So, what’s the best way? A marriage wrote to the editor of the Harvard Men’s Health Watch, saying their spouse wants to have pizza for his prostate but they don’t think it’s a healthful food. The doctor replied with such suggestions of a “cheese-free pizza( with broccoli instead of pepperoni, please) ” or just some “tomato juice.”

Why eat tomato sauce when you can just take lycopene augments? See my video Lycopene Supplements vs. Prostate Cancer.

Are there any menus we should eschew? Check out, for example, Prostate Cancer Survival: The A/ V Ratio and How Our Gut Bacteria Can Use Eggs to Accelerate Cancer.

We may be able to prevent cancer and even make the progression of cancer with diet. See:

Cancer Reversal Through Diet ? From Table to Able: Combating Disabling Diseases with Food Treating Advanced Prostate Cancer with Diet: Part 1 Treating Advanced Prostate Cancer with Diet: Part 2 How Not to Die from Cancer The Best Advice on Diet and Cancer Does Heme Iron Cause Cancer ? How to Win the War on Cancer Can Alcohol Cause Cancer ? Benefits of Nutritional Yeast for Cancer

It isn’t always easy to get guys to change, though. See Changing a Man’s Diet After a Prostate Cancer Diagnosis.

In health,

Michael Greger, M.D.

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2019: Evidence-Based Weight Loss 2016: How Not To Die: The Role of Diet in Preventing, Arresting, and Reversing Our Top 15 Killers 2015: Food as Medicine: Preventing and Treating the Most Dreaded Diseases with Diet 2014: From Table to Able: Combating Disabling Diseases with Food 2013: More Than an Apple a Day 2012: Uprooting the Leading Causes of Death

Read more: nutritionfacts.org