Avocado consumption can improve artery function, but what impacts might guacamole have on cancer risk?
In my last-place video about avocados, The Effects of Avocados and Red Wine on Meal-Induced Inflammation, I described their anti-inflammatory aftermaths and cholesterol- and triglyceride-lowering upshots, but what about the Are Avocados Good for You ? video I did years ago about the chromosome-damaging effects in a petri food? That goes back to 1975, when a pesticide naturally produced by the avocado tree was discovered, thought to explain why lactating livestock suffer mammary gland damage after pecking on the buds. The poison, reputation persin, was also found to be damaging to the heart, which is why you should never feed avocado to your baby birds.
But, if persin attacks mammary cadres in swine, might it assault breast cancer cells in humans? As you can see at 0:52 in my video Are Avocados Healthy ?, it did seem to have the same kind of cellular cytoskeleton-clumping effect in vitro that chemotherapy can have, illustrating potent cell raise stopping and killing effects of the tale weed poison among many texts of human breast cancer cells. So, researchers are thinking about how it might one day be used as chemo itself, but I’m thinking, Holy guacamole, Batman! Please tell me it doesn’t have toxic effects on normal cadres, too.
We got an answer in 2010 with an evaluation of the genotoxicity–the toxicity to our chromosomes–of avocado extracts on human white blood cells in a petri recipe. As you can see at 1:35 in my video , commonly, less than 10 percent of our dividing cells have any chromosome abnormalities, but if you drip some avocado fruit extracts on them, up to half come out imperfect in some way. The investigates concluded that there’s something in avocado fruit that “can potentially generate substantial genomic instability and some genetic detriment in human lymphocytes in vitro, ” that is, in white blood cells in a petri bowl. If the same effect occurs in actual parties, it could, for example, result in transforming cadres into cancer. That is a big if, though. These were blood cells. You don’t inject guacamole into the vein. For something to get into our bloodstream, it first has to survive our gut battery-acid, get absorbed through our entrails, and then sneak past our liver’s detoxification enzymes. And indeed, persin may have an impact, amended by acidic status. So, given all the differences between what happens in a petri meal and inside a person, it’s essential to carry out further studies “before making a final note on the genotoxicity.” Sounds rational, but what do you do before these studies come out? I was concerned fairly that I provisionally moved avocados from being a don’t-hold-back green-light food to a moderate-your-intake yellow-light food to stray on the two sides of caution until we knew more.
Even if persin were utterly destroyed by stomach acid, what about oral cancer? As “youre seeing” at 3:01 in my video, avocado obtains at high enough accumulations can harm the growth of the kinds of cells that course our openings. This was in a petri food, though, where the avocado is coming in direct contact with the cells–but that’s too kind of what happens in your speak when you eat it. However, it injures oral cancer cadres even more. At 3:32 in my video, “youre seeing” a cluster of oral cancer cadres. In the first image, the mitochondria, the power plants of the cadres fueling cancer rise, are seen in red. In the second image, you can see they’ve been obliterated by the avocado extract–no more red-colored mitochondria. Since it does this more to cancerous cadres than normal cadres, the researchers conclude that avocados may end up preventing cancer.
What about the esophagus, which lies between the mouth and the belly? Researchers similarly found that an avocado fruit extract appeared to inhibit cancer cell growth more than ordinary cadre emergence when it came to both colon cancer cadres and esophageal cancer cadres, as “youre seeing” at 3:53 in my video. But, rather than comparing the effects to ordinary colon and esophagus cadres, they compared them to a type of blood cell, which, again, is of restriction relevant in a petri meal study of something you eat.
A study I found to be pretty exciting looked at p-cresol, which is a “uremic toxin” and may also be toxic to the liver. “Found to be associated with autism, ” it comes from eating high-protein diets, whereas if you munched a more plant-based food, which is the only source of prebiotics like fiber and resistant starch, your elevations go down. See, fermentation of carbohydrates in the colon, like fiber, is considered beneficial, whereas fermentation of protein, which is called putrefaction, is considered detrimental. So, if you switch beings to a high-protein diet, within days, the excess protein putrefying in their gut leads to an increase in ammonia as well as p-cresol–in fact, a doubling of degrees within a few weeks. But, might phytonutrient-rich plant foods, like apples, cranberries, grapes, or avocados, protect the cells ordering our colon “from the deleterious effects of p-cresol…in terms of cell viability, mitochondrial office, and epithelial coherence, ” meaning protection against gut leakiness? At 5:12 in my video, I demonstrate the data on barrier function integrity. You can see that it is damaged by p-cresol, but rescued by all the cranberry, avocado, grape, and apple obtains. Mitochondrial perform, however, was only improved by the cranberries and avocados, which also were the only ones that appeared to prevent the deleterious effect of p-cresol on colon cadre viability. The bottom line, though, is that avocados appear to have beneficial effects on colon rowing cadres. Okay, but enough of these in vitro studies, already. Yes, an avocado remove can inhibit cancer cell expansion in a petri bowl, but unless you’re doing some heinous things to that avocado–like guacamole with benefits–there’s no way that avocado is going to come in direct contact with your prostate cadres. So, what does this study want?
This is why I was so excited to see the first study to actually look for a link between avocado consumption and prostate cancer. Actual human beings eating avocados! So, do avocado eaters have more cancer probability or less cancer probability? Men who feed the most avocado, more than about a third of an avocado a era, had shortened probability of prostate cancer–in fact, less than half the stranges. So, with the data on improved vein role, lower cholesterol, and, if anything, an association with abridged cancer likelihood, I’d indicate moving avocados back up with the other green-light foods.
How Not to Die from Cancer gave an overview on dietary approachings to cancer prevention and treatment, and I also have several hundreds of videos on all of the common cancers.
What if you’ve already been diagnosed? Even if you already have prostate cancer, for example, it’s not too late to improve your nutrition. See:
Prostate Cancer Survival: The A/ V Ratio Eggs, Choline, and Cancer Prostate Cancer and Organic Milk vs. Almond Milk Pomegranate vs. Placebo for Prostate Cancer Best Supplements for Prostate Cancer Preventing Prostate Cancer with Green Tea Treating Prostate Cancer with Green Tea Changing a Man’s Diet After a Prostate Cancer Diagnosis Treating Advanced Prostate Cancer with Diet: Part 1 Treating Advanced Prostate Cancer with Diet: Part 2 Tomato Sauce vs. Prostate Cancer Lycopene Supplements vs. Prostate Cancer
Michael Greger, M.D.
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2019: Evidence-Based Weight Loss 2016: How Not To Die: The Role of Diet in Preventing, Arresting, and Reversing Our Top 15 Killers 2015: Food as Medicine: Preventing and Treating the Most Dreaded Diseases with Diet 2014: From Table to Able: Combating Disabling Diseases with Food 2013: More Than an Apple a Day 2012: Uprooting the Leading Causes of Death
Read more: nutritionfacts.org