The carbohydrate-insulin model of obesity posits that high-carbohydrate diets lead to excess insulin secretion, thereby promoting overweight growth and increasing energy intake. Thus, low-carbohydrate diets are predicted to reduce ad libitum energy intake as compared to low-fat, high-carbohydrate foods. To test this hypothesis, 20 adults aged 29.9 +- 1.4( aim +- s.e.m .) years with body mass index of 27.8 +- 1.3 kg m-2 were admitted as inpatients to the National Academy of Health Clinical Center and randomized to destroy ad libitum either a minimally processed, plant-based, low-fat diet( 10.3% fat, 75.2% carbohydrate) with high glycemic loading (8 5 g 1,000 kcal -1) or a minimally handled, animal-based, ketogenic, low-carbohydrate diet( 75.8% fatty, 10.0% carbohydrate) with low-toned glycemic loading( 6 g 1,000 kcal -1) for 2 weeks followed immediately by the alternate diet for “two weeks “. One player withdrew due to hypoglycemia during the low-carbohydrate diet. The primary sequels likened mean daily ad libitum energy intake between each 2-week diet period as well as between the final week of each diet. We found that the low-fat diet led to 689 +- 73 kcal d-1 less vitality intake than the low-carbohydrate diet over 2 weeks( P< 0.0001) and 544 +- 68 kcal d-1 less over the final week( P< 0.0001 ). Therefore, the predictions of the carbohydrate-insulin model were inconsistent with our observations.
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